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Clinical Revival of the Pulse Pressure Waveform? Todd Hurst , MD, and A. Abstract The arterial pulse has historically been an essential source of information in the clinical assessment of health. With current sphygmomanometric and oscillometric devices, only the peak and trough of the peripheral arterial pulse waveform are clinically used. Several limitations exist with peripheral blood pressure. First, central aortic pressure is a better predictor of cardiovascular outcome than peripheral pressure. Second, peripherally obtained blood pressure does not accurately reflect central pressure because of pressure amplification.

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The northern branch of the A41 motorway passes to the east of the town, allowing direct access to Annecy and then later, by the continuity of the A40 , into the city of Geneva. Two junctions 13 and 14 serve the commune, one to the south, the other to the north. Aix-les-Bains is also accessible by train. It was one of the earliest European municipalities to host a rail network in its territory when it was administered by the Dukes of Savoie.

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See Article History Alternative Titles: Area city proper, 93 square miles square kilometres ; metropolitan area , square miles square kilometres. After Provence joined the Kingdom of France in the 15th century, Marseille retained a separate administration and continually engaged in spirited revolt against kings or governments that threatened its liberties.

Frenchmen elsewhere, convinced that the Mediterranean climes of Provence could never be fully integrated into either the French realm or the Gallic spirit, long looked upon Marseille as a sort of folkloric institution: By whatever proportion fact may have been coloured with myth in its image, Marseille undoubtedly forms a major element in the economic and social structure of France. Under the Socialist mayor Gaston Defferre , whose administration, from until his death in , was the longest in its history, Marseille experienced major transformation—a process that is still continuing.

Physical and human geography The character of Marseille has been determined to a great extent by geographic location. The trading port founded by Greeks from the city of Phocaea in about bc was to attract both settlers and visitors.

AIX

Prehistoric Provence[ edit ] The entrance to the Cosquer Cave , decorated with paintings of auks, bison, seals and outlines of hands dating to 27, to 19, BC, is located 37 meters under the surface of the Calanque de Morgiou near Cassis. A bronze-age dolmen to BC near Draguignan The coast of Provence has some of the earliest known sites of human habitation in Europe.

Primitive stone tools dated to 1 to 1. At the beginning of the Paleolithic period, the sea level in western Provence was meters higher than it is today. By the end of the Paleolithic, it had dropped to metres lower than today"s sea level. The cave dwellings of the early inhabitants of Provence were regularly inundated by the rising sea or left far from the sea and swept away by erosion.

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It was a huge hit. So much so that it returns in on February to Marseille, one of just four cities hosting the event this year. This year you"ll have to pay for a ticket: Can"t make it to Marseille in mid-February? Watch the clip below to get the flavour of this thrilling race. This display is orchestrated by Groupe F, a world-renowned company of pyrotechnicians from Provence, and should be something pretty special. Entry to Marseille"s city museums will be free too on the 14, 17 and 18 February, when a number of activities for families are organised all across town.

Over the weekend of February the theatres of Aix en Provence are also organising special events, from a sneak preview of Orfeo et Majnun, a new operatic love story, to"sexy breakfasts" whatever that might mean and the chance to spend a whole night in one of the theatres. Click here for details. And Arles isn"t left out of the party either. Les Suds, its summer music festival, is holding a special winter edition this year called Les Suds en Hiver , with concerts in Arles itself, Tarascon and other towns in the area.

Between then and the end of August there will be some cultural events across the region. They include street festivals, major exhibitions, operas, concerts, circuses and dance performances.

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Prehistoric Provence[ edit ] The entrance to the Cosquer Cave , decorated with paintings of auks , bison, seals and outlines of hands dating to 27, to 19, BC, is located 37 meters under the surface of the Calanque de Morgiou near Cassis. A bronze-age dolmen to BC near Draguignan The coast of Provence has some of the earliest known sites of human habitation in Europe. Primitive stone tools dating back 1 to 1. Two ice ages came and went, the sea level changed dramatically. At the beginning of the Paleolithic, the sea level in western Provence was meters higher than today.

By the end of the Paleolithic, it had dropped to to metres below the sea level today.

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Do[ edit ][ add listing ] Sit on the Market place central city on a summer evening, watch students strolling by, listen to guitar players and have a beer. Large and very well known spa, sauna and wellness place. The Lousberg is a hill m right next to the historic city center. A paved road leads up the hill and in about 20 minutes one can reach the top with a watch tower and some binoculars.

Expect great views of the city center, the Tivoli football stadium and the surrounding nature. Public swimming pool, popular with school and university students in summer. Facilities include a meadow for sunbathing, a diving platform, table tennis and beach volleyball, a 50m pool for swimming, a kids pool. The Aachen Christmas Market is famous all over Europe for its nice setting between cathedral, town hall and other historic buildings.

Aachen has been known as a spa town for centuries. Due to the sulfur, the area will usually smell like rotten eggs. Locals and visitors drank the water for its healing powers.

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Trafalgar guarantees to quote you the lowest possible airfare available on the day that you book. Please note that airfares are not included in the prices above. Departure 13 July will be in Paris on Bastille Day. Celebrations will be taking place throughout Paris. Travel to Europe often requires an overnight flight. Please arrange flights to arrive on or before Day 1.

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During the following years the line has been continuously extended towards the Mediterranean until it reached Marseille in Frequent TGV trains connect Paris with the second and third largest cities of France, bringing you in just about two hours to Lyon and in roughly three hours to Marseille. The Tickets Tickets for all trains are available online at Trainline or Voyages-SNCF — thank you for using our partner link to book your tickets at no extra costs and supporting railcc.

Trainline is a great booking tools for trains in France. It requires a free registration but is very easy to handle and gives you the best available prices. Of course tickets are also available locally at ticket desks or ticket machines at stations. If you have to board a train without a ticket, immediately look for the conductor to avoid being fined. In principle, there are three different fares available: No return or exchange; these are usually the cheapest but have limited availability and have to be purchased well in advance Loisir: Free return or exchange until one day prior to departure; more expensive than Prem but usually available until one day prior to depature; the earlier you book the more you save compared to Pro Pro: Free return or exchange; available until departure, full fare Several reductions are available for travellers under 26 and from 60 years of age as well as for concession card holders.

TGV require compulsory reservation which is included in regular tickets. If you are travelling with a Rail Pass such as Interrail or Eurail you can book this reservation easily online at rail. This more expensive reservation is available anytime as long as the train is not fully booked and not limited.

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Aix en Provence Why Choose PPG For over twenty years we have built a network of the best professional agents in the most desirable locations. We offer our clients a personal service, at no extra expense. We make sure that buying your overseas property, from initial viewings to final purchase, goes as smoothly as possible. With good airport links to both Marseille and Nice and an excellent high speed train link to the rest of France, Aix-en-Provence property offers investors an excellent opportunity to own or rent property in this beautiful region of France.

There is lots to see and do in Aix-en-Provence. Aix-en-Provence property prices remain high compared to the rest of South West France and are likely to remain so as demand for Aix-en-Provence property is also very healthy as the excellent year round rental opportunities are proving to be increasingly attractive to international investors.

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The quickest flight from Marseille Airport to Toulouse Airport is the direct flight which takes 1 h. Where does the Aix-en-Provence to Toulouse bus arrive? Aix-en-Provence to Toulouse bus services, operated by Ouibus, arrive at Toulouse station. Where does the Aix-en-Provence to Toulouse train arrive? Yes, the driving distance between Aix-en-Provence to Toulouse is km.

It takes approximately 3 h 43 min to drive from Aix-en-Provence to Toulouse.

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He was taken prisoner and held for a year, but was eventually released unharmed. He felt inspired to do the same, and started traveling around preaching repentance in poverty. John Lateran is the cathedral church of the diocese of Rome, and thus possibly representative of the Church in general, but especially the papacy. Dominic there The Fourth Lateran Council was the 12th ecumenical council of the Catholic Church and affirmed transubstantiation and papal primacy, among other things.

Dominic, founder of the Order of Preachers or Dominicans, was also present. He preached before the Sultan. Francis offered to go first, but the Sultan turned down the challenge.

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